Classical and alternative activation of mononuclear phagocytes: picking the best of both worlds for tumor promotion
JOA Van Ginderachter, K Movahedi, GH Ghassabeh… - Immunobiology, 2006 - Elsevier
Mononuclear phagocytes often function as control switches of the immune system, securing
the balance between pro-and anti-inflammatory reactions. For this purpose and depending
on the activating stimuli, these cells can develop into different subsets: classically (M1) or
alternatively (M2) activated mononuclear phagocytes, the molecular and functional
characterization of which is a current topic of investigation. Accumulating evidence suggests
that cells of the monocyte/macrophage lineage can be hijacked by tumors for their own …
the balance between pro-and anti-inflammatory reactions. For this purpose and depending
on the activating stimuli, these cells can develop into different subsets: classically (M1) or
alternatively (M2) activated mononuclear phagocytes, the molecular and functional
characterization of which is a current topic of investigation. Accumulating evidence suggests
that cells of the monocyte/macrophage lineage can be hijacked by tumors for their own …
