Calpain inhibition decreases endothelin-1 levels and pulmonary hypertension after cardiopulmonary bypass with deep hypothermic circulatory arrest
JY Duffy, SM Schwartz, JM Lyons, JH Bell… - Critical care …, 2005 - journals.lww.com
Objective: Cardiopulmonary bypass in infants and children can result in cardiopulmonary
dysfunction through ischemia and reperfusion injury. Pulmonary hypertension and injury are
particularly common and morbid complications of neonatal cardiac surgery. Inhibition of
calpain, a cysteine protease, has been shown to inhibit reperfusion injury in adult organ
systems. The hypothesis is that calpain inhibition can alleviate the cardiopulmonary
dysfunction seen in immature animals following ischemia and reperfusion with …
dysfunction through ischemia and reperfusion injury. Pulmonary hypertension and injury are
particularly common and morbid complications of neonatal cardiac surgery. Inhibition of
calpain, a cysteine protease, has been shown to inhibit reperfusion injury in adult organ
systems. The hypothesis is that calpain inhibition can alleviate the cardiopulmonary
dysfunction seen in immature animals following ischemia and reperfusion with …
