Short-term caloric restriction (CR) protects the young myocardium against
ischemia/reperfusion (I/R) injury through a mechanism involving AMP-activated protein
kinase (AMPK). Here we ask whether a life-long CR intervention can extend this protection
to the aged myocardium, and whether AMP-activated protein kinase (AMPK) plays a role in
that protection. Hearts from ad libitum fed (AL) and life-long calorically restricted (LCR) mice
were examined at 30 months of age by 25/90min global I/R, with and without AMPK …