The diagnosis of gastric epithelial dysplasia, a precursor lesion of gastric adenocarcinoma,
is hindered by interobserver variability and by its resemblance to regenerative changes.
Loss of cell polarity, a histological feature of gastric epithelial dysplasia, may be difficult to
ascertain, especially in the setting of inflammation or injury. A biomarker of cell polarity could
be useful in diagnosis of dysplasia, but has not been reported. The Lethal giant larvae (lgl)
gene controls apical–basal polarity of epithelial cells in Drosophila, and has properties of a …