A large body of work on Drosophila melanogaster has identified and characterized a
number of key polarity regulators, many of which are required for the regulation of multiple
other processes including proliferation, migration, invasion, and tumorigenesis. Humans
possess either single or multiple homologues of each of the Drosophila polarity proteins,
and in most cases, these are highly conserved between species, implying an important and
conserved function for each of the polarity complexes. Recent studies in cultured …