Role of the peripheral benzodiazepine receptor in sensory neuron regeneration
CD Mills, JL Bitler, CJ Woolf - Molecular and Cellular Neuroscience, 2005 - Elsevier
Peripheral benzodiazepine receptor (PBR) expression increases in small dorsal root
ganglion (DRG) sensory neurons after peripheral nerve injury. To determine the functional
significance of this induction, we evaluated the effects of PBR ligands on rodent sensory
axon outgrowth. In vitro, Ro5-4864, a PBR agonist, enhanced outgrowth only of small
peripherin-positive DRG neurons. When DRG cells were preconditioned into an active
growth state by a prior peripheral nerve injury Ro5-4864 augmented and PK 11195, a PBR …
ganglion (DRG) sensory neurons after peripheral nerve injury. To determine the functional
significance of this induction, we evaluated the effects of PBR ligands on rodent sensory
axon outgrowth. In vitro, Ro5-4864, a PBR agonist, enhanced outgrowth only of small
peripherin-positive DRG neurons. When DRG cells were preconditioned into an active
growth state by a prior peripheral nerve injury Ro5-4864 augmented and PK 11195, a PBR …