Arterial thrombosis, a major cause of myocardial infarction and stroke, is initiated by
activation of blood platelets by subendothelial collagen. The protein kinase C (PKC) family
centrally regulates platelet activation, and it is becoming clear that the individual PKC
isoforms play distinct roles, some of which oppose each other. Here, for the first time, we
address all four of the major platelet-expressed PKC isoforms, determining their comparative
roles in regulating platelet adhesion to collagen and their subsequent activation under …