[HTML][HTML] Constitutive production of NF-κB2 p52 is not tumorigenic but predisposes mice to inflammatory autoimmune disease by repressing Bim expression
Z Wang, B Zhang, L Yang, J Ding, HF Ding - Journal of biological chemistry, 2008 - ASBMB
Normal development of the immune system requires regulated processing of NF-κB2 p100
to p52, which activates NF-κB2 signaling. Constitutive production of p52 has been
suggested as a major mechanism underlying lymphomagenesis induced by NF-κB2
mutations, which occur recurrently in a variety of human lymphoid malignancies. To test the
hypothesis, we generated transgenic mice with targeted expression of p52 in lymphocytes.
In contrast to their counterparts expressing the tumor-derived NF-κB2 mutant p80HT, which …
to p52, which activates NF-κB2 signaling. Constitutive production of p52 has been
suggested as a major mechanism underlying lymphomagenesis induced by NF-κB2
mutations, which occur recurrently in a variety of human lymphoid malignancies. To test the
hypothesis, we generated transgenic mice with targeted expression of p52 in lymphocytes.
In contrast to their counterparts expressing the tumor-derived NF-κB2 mutant p80HT, which …
