The marine compound spisulosine, an inhibitor of cell proliferation, promotes the disassembly of actin stress fibers
R Cuadros, EM De Garcini, F Wandosell, G Faircloth… - Cancer letters, 2000 - Elsevier
R Cuadros, EM De Garcini, F Wandosell, G Faircloth, JM Fernandez-Sousa, J Avila
Cancer letters, 2000•ElsevierSpisulosine is a novel antiproliferative (antitumoral) compound of marine origin. In this work
the molecular target for this toxic agent has been analyzed. In the presence of spisulosine,
cultured cells change their morphology, first acquiring a fusiform morphology, and later
becoming rounded without focal adhesions. Analysis of the cytoskeleton of treated cells
indicate the absence of actin stress fibers.
the molecular target for this toxic agent has been analyzed. In the presence of spisulosine,
cultured cells change their morphology, first acquiring a fusiform morphology, and later
becoming rounded without focal adhesions. Analysis of the cytoskeleton of treated cells
indicate the absence of actin stress fibers.
Spisulosine is a novel antiproliferative (antitumoral) compound of marine origin. In this work the molecular target for this toxic agent has been analyzed. In the presence of spisulosine, cultured cells change their morphology, first acquiring a fusiform morphology, and later becoming rounded without focal adhesions. Analysis of the cytoskeleton of treated cells indicate the absence of actin stress fibers.
Elsevier
