The function of KGF in morphogenesis of epithelium and reepithelialization of wounds
S Werner, H Smola, X Liao, MT Longaker, T Krieg… - Science, 1994 - science.org
S Werner, H Smola, X Liao, MT Longaker, T Krieg, PH Hofschneider, LT Williams
Science, 1994•science.orgThe function of keratinocyte growth factor (KGF) in normal and wounded skin was assessed
by expression of a dominant-negative KGF receptor transgene in basal keratinocytes. The
skin of transgenic mice was characterized by epidermal atrophy, abnormalities in the hair
follicles, and dermal hyperthickening. Upon skin injury, inhibition of KGF receptor signaling
reduced the proliferation rate of epidermal keratinocytes at the wound edge, resulting in
substantially delayed reepithelialization of the wound.
by expression of a dominant-negative KGF receptor transgene in basal keratinocytes. The
skin of transgenic mice was characterized by epidermal atrophy, abnormalities in the hair
follicles, and dermal hyperthickening. Upon skin injury, inhibition of KGF receptor signaling
reduced the proliferation rate of epidermal keratinocytes at the wound edge, resulting in
substantially delayed reepithelialization of the wound.
The function of keratinocyte growth factor (KGF) in normal and wounded skin was assessed by expression of a dominant-negative KGF receptor transgene in basal keratinocytes. The skin of transgenic mice was characterized by epidermal atrophy, abnormalities in the hair follicles, and dermal hyperthickening. Upon skin injury, inhibition of KGF receptor signaling reduced the proliferation rate of epidermal keratinocytes at the wound edge, resulting in substantially delayed reepithelialization of the wound.
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