p38δ mitogen-activated protein kinase regulates skin homeostasis and tumorigenesis

T Efimova - Cell Cycle, 2010 - Taylor & Francis
Cell Cycle, 2010Taylor & Francis
The p38δ mitogen-activated protein kinase (MAPK) is abundantly expressed in a wide array
of tissues where it is likely to have specific functions. This review aims to highlight recent
new insights into the biological roles of this relatively less studied p38 isoform. We focus on
function of p38δ in regulating of epidermal keratinocyte differentiation, apoptosis and skin
tumor development.
The p38δ mitogen-activated protein kinase (MAPK) is abundantly expressed in a wide array of tissues where it is likely to have specific functions. This review aims to highlight recent new insights into the biological roles of this relatively less studied p38 isoform. We focus on function of p38δ in regulating of epidermal keratinocyte differentiation, apoptosis and skin tumor development.
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