The BCL‐2 family of apoptotic proteins regulates the critical balance between cellular life
and death and, thus, has become the focus of intensive basic science inquiry and a
fundamental target for therapeutic development in oncology and other diseases. Classified
based on the presence of conserved α‐helical motifs and pro‐and anti‐apoptotic
functionalities, BCL‐2 proteins participate in a complex interaction network that determines
cellular fate. The identification of BCL‐2 homology domain 3 (BH3) as a critical death helix …