Mitochondrial respiratory chain activity in the human brain as a function of age
J Ojaimi, CL Masters, K Opeskin, P McKelvie… - Mechanisms of ageing …, 1999 - Elsevier
Age-associated changes in mitochondrial respiratory chain activity were investigated in
human brain tissue collected at autopsy. Four brain regions, the frontal cortex, superior
temporal cortex, cerebellum and putamen, were studied to map any regional variation. A
significant decrease in cytochrome c oxidase activity was seen in all regions studied with
increasing age (P< 0.05). Although a small decrease in succinate dehydrogenase-
cytochrome c oxidoreductase and NADH: ubiquinone oxidoreductase activities was …
human brain tissue collected at autopsy. Four brain regions, the frontal cortex, superior
temporal cortex, cerebellum and putamen, were studied to map any regional variation. A
significant decrease in cytochrome c oxidase activity was seen in all regions studied with
increasing age (P< 0.05). Although a small decrease in succinate dehydrogenase-
cytochrome c oxidoreductase and NADH: ubiquinone oxidoreductase activities was …
