[HTML][HTML] Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases
The hypoglycemic effects of high dose salicylates in the treatment of diabetes were
documented before the advent of insulin. However, the molecular mechanisms by which
salicylates exert these anti-diabetic effects are not well understood. In this study, we
analyzed the effects of aspirin (acetylsalicylic acid) on serine phosphorylation of insulin
receptor substrate 1 (IRS-1) in cells treated with tumor necrosis factor (TNF)-α.
Phosphorylation of IRS-1 at Ser 307, Ser 267, and Ser 612 was monitored by …
documented before the advent of insulin. However, the molecular mechanisms by which
salicylates exert these anti-diabetic effects are not well understood. In this study, we
analyzed the effects of aspirin (acetylsalicylic acid) on serine phosphorylation of insulin
receptor substrate 1 (IRS-1) in cells treated with tumor necrosis factor (TNF)-α.
Phosphorylation of IRS-1 at Ser 307, Ser 267, and Ser 612 was monitored by …