Protective effect of milk fat globule-epidermal growth factor-factor VIII after renal ischemia-reperfusion injury in mice
A Matsuda, R Wu, A Jacob, H Komura… - Critical care …, 2011 - journals.lww.com
Objectives: Renal ischemia-reperfusion injury causes acute renal failure, and the hallmarks
of renal ischemia-reperfusion injury are inflammation, apoptosis, necrosis, and capillary
dysfunction. Milk fat globule-epidermal growth factor-factor VIII (MFG-E8), a membrane-
associated secretory glycoprotein, is produced by immune cells and reported to participate
in multiple physiologic processes associated with tissue remodeling. We have recently
shown that MFG-E8 treatment attenuates organ injury, inflammatory responses, and survival …
of renal ischemia-reperfusion injury are inflammation, apoptosis, necrosis, and capillary
dysfunction. Milk fat globule-epidermal growth factor-factor VIII (MFG-E8), a membrane-
associated secretory glycoprotein, is produced by immune cells and reported to participate
in multiple physiologic processes associated with tissue remodeling. We have recently
shown that MFG-E8 treatment attenuates organ injury, inflammatory responses, and survival …