Phospholipid transfer protein (PLTP) is a multifunctional protein synthesized by various cell
types and secreted into the plasma. Plasma PLTP is able to transfer phospholipids between
lipoproteins and modulate HDL particles. Mice with overexpression of human PLTP have an
increased ability to generate preβ-HDL, reduced total HDL levels and an increased
susceptibility to atherosclerosis. As the macrophage is a key component of the
atherosclerotic lesion and an important site of PLTP expression, we investigated the role of …