Reversing histone methylation
AJ Bannister, T Kouzarides - Nature, 2005 - nature.com
Nature, 2005•nature.com
Histones package DNA, and post-translational modifications of histones can regulate access
to DNA. Until recently, histone methylation—unlike all other histone modifications—was
considered a permanent mark. The discovery of enzymes that reverse the methylation of
lysines and arginines challenges our current thinking on the unique nature of histone
methylation, and substantially increases the complexity of histone modification pathways.
to DNA. Until recently, histone methylation—unlike all other histone modifications—was
considered a permanent mark. The discovery of enzymes that reverse the methylation of
lysines and arginines challenges our current thinking on the unique nature of histone
methylation, and substantially increases the complexity of histone modification pathways.
Abstract
Histones package DNA, and post-translational modifications of histones can regulate access to DNA. Until recently, histone methylation—unlike all other histone modifications—was considered a permanent mark. The discovery of enzymes that reverse the methylation of lysines and arginines challenges our current thinking on the unique nature of histone methylation, and substantially increases the complexity of histone modification pathways.
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