Hepatic heparan sulfate proteoglycans and endocytic clearance of triglyceride-rich lipoproteins
EM Foley, JD Esko - Progress in molecular biology and translational …, 2010 - Elsevier
Hypertriglyceridemia, characterized by the accumulation of triglyceride-rich lipoproteins in
the blood, affects 10–20% of the population in western countries and increases the risk of
atherosclerosis, coronary artery disease, and pancreatitis. The etiology of
hypertriglyceridemia is complex, and much interest exists in identifying and characterizing
the biological and environmental factors that affect the synthesis and turnover of plasma
triglycerides. Genetic studies in mice have recently identified that heparan sulfate …
the blood, affects 10–20% of the population in western countries and increases the risk of
atherosclerosis, coronary artery disease, and pancreatitis. The etiology of
hypertriglyceridemia is complex, and much interest exists in identifying and characterizing
the biological and environmental factors that affect the synthesis and turnover of plasma
triglycerides. Genetic studies in mice have recently identified that heparan sulfate …
