Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation
SW Jang, SJ Yang, S Srinivasan, K Ye - Journal of biological chemistry, 2007 - ASBMB
Oxidative stress can induce apoptosis through activation of MstI, subsequent
phosphorylation of FOXO and nuclear translocation. MstI is a common component of
apoptosis initiated by various stresses. MstI kinase activation requires autophosphorylation
and proteolytic degradation by caspases. The role of Akt in regulating MstI activity has not
been previously examined. Here, we show that MstI is a physiological substrate of Akt. Akt
phosphorylation of MstI diminishes its apoptotic cleavage by caspases and prevents its …
phosphorylation of FOXO and nuclear translocation. MstI is a common component of
apoptosis initiated by various stresses. MstI kinase activation requires autophosphorylation
and proteolytic degradation by caspases. The role of Akt in regulating MstI activity has not
been previously examined. Here, we show that MstI is a physiological substrate of Akt. Akt
phosphorylation of MstI diminishes its apoptotic cleavage by caspases and prevents its …
