[HTML][HTML] NF-κB functions in stromal fibroblasts to regulate early postnatal muscle development
Classical NF-κB activity functions as an inhibitor of the skeletal muscle myogenic program.
Recent findings reveal that even in newborn RelA/p65−/− mice, myofiber numbers are
increased over that of wild type mice, suggesting that NF-κB may be a contributing factor in
early postnatal skeletal muscle development. Here we show that in addition to p65
deficiency, repression of NF-κB with the IκBα-SR transdominant inhibitor or with muscle-
specific deletion of IKKβ resulted in similar increases in total fiber numbers as well as an up …
Recent findings reveal that even in newborn RelA/p65−/− mice, myofiber numbers are
increased over that of wild type mice, suggesting that NF-κB may be a contributing factor in
early postnatal skeletal muscle development. Here we show that in addition to p65
deficiency, repression of NF-κB with the IκBα-SR transdominant inhibitor or with muscle-
specific deletion of IKKβ resulted in similar increases in total fiber numbers as well as an up …
