Anakinra is safe and effective in controlling hyperimmunoglobulinaemia D syndrome-associated febrile crisis
M Cailliez, F Garaix, C Rousset-Rouviere… - Journal of inherited …, 2006 - Springer
M Cailliez, F Garaix, C Rousset-Rouviere, D Bruno, I Kone-Paut, J Sarles, B Chabrol…
Journal of inherited metabolic disease, 2006•SpringerHyper-IgD and periodic fever syndrome (HIDS) is a hereditary autoinflammatory syndrome,
characterized by recurrent inflammatory attacks. Treatment of HIDS is difficult. Recently, the
IL-1ra analogue anakinra was reported to be successful in aborting the IgD inflammatory
attacks in a vaccination model. We report a clinical case of spectacular reduction of febrile
attacks in a severe HIDS patient.
characterized by recurrent inflammatory attacks. Treatment of HIDS is difficult. Recently, the
IL-1ra analogue anakinra was reported to be successful in aborting the IgD inflammatory
attacks in a vaccination model. We report a clinical case of spectacular reduction of febrile
attacks in a severe HIDS patient.
Summary
Hyper-IgD and periodic fever syndrome (HIDS) is a hereditary autoinflammatory syndrome, characterized by recurrent inflammatory attacks. Treatment of HIDS is difficult. Recently, the IL-1ra analogue anakinra was reported to be successful in aborting the IgD inflammatory attacks in a vaccination model. We report a clinical case of spectacular reduction of febrile attacks in a severe HIDS patient.
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