Immune suppression in the tumor microenvironment: a role for dendritic cell-mediated tolerization of T cells
AA Hurwitz, SK Watkins - Cancer Immunology, Immunotherapy, 2012 - Springer
AA Hurwitz, SK Watkins
Cancer Immunology, Immunotherapy, 2012•SpringerImmune suppression remains a consistent obstacle to successful anti-tumor immune
responses. As tumors develop, they create a microenvironment that not only supports tumor
growth and metastasis but also reduces potential adaptive immunity to tumor antigens.
Among the many components of this tumor microenvironment is a population of dendritic
cells which exert profound immune suppressive effects on T cells. In this review, we discuss
our recent findings related to these tumor-associated dendritic cells and how targeting them …
responses. As tumors develop, they create a microenvironment that not only supports tumor
growth and metastasis but also reduces potential adaptive immunity to tumor antigens.
Among the many components of this tumor microenvironment is a population of dendritic
cells which exert profound immune suppressive effects on T cells. In this review, we discuss
our recent findings related to these tumor-associated dendritic cells and how targeting them …
Abstract
Immune suppression remains a consistent obstacle to successful anti-tumor immune responses. As tumors develop, they create a microenvironment that not only supports tumor growth and metastasis but also reduces potential adaptive immunity to tumor antigens. Among the many components of this tumor microenvironment is a population of dendritic cells which exert profound immune suppressive effects on T cells. In this review, we discuss our recent findings related to these tumor-associated dendritic cells and how targeting them may serve to generate more durable anti-tumor immune responses.
Springer
