The E3 ubiquitin ligase Itch in T cell activation, differentiation, and tolerance
YC Liu - Seminars in immunology, 2007 - Elsevier
Seminars in immunology, 2007•Elsevier
Tagging a small molecule ubiquitin to a protein substrate, or protein ubiquitination, plays an
important role in the immune responses. This process is catalyzed by a cascade of
enzymatic reactions, with the E3 ubiquitin ligases being the critical enzymes that determine
the specificity of substrate recognition. The E3 ligase Itch was identified from a mutant
mouse which displays skin scratching and abnormal immune disorders. In the past few
years, much progress has been made in our understanding of Itch-promoted protein …
important role in the immune responses. This process is catalyzed by a cascade of
enzymatic reactions, with the E3 ubiquitin ligases being the critical enzymes that determine
the specificity of substrate recognition. The E3 ligase Itch was identified from a mutant
mouse which displays skin scratching and abnormal immune disorders. In the past few
years, much progress has been made in our understanding of Itch-promoted protein …
Tagging a small molecule ubiquitin to a protein substrate, or protein ubiquitination, plays an important role in the immune responses. This process is catalyzed by a cascade of enzymatic reactions, with the E3 ubiquitin ligases being the critical enzymes that determine the specificity of substrate recognition. The E3 ligase Itch was identified from a mutant mouse which displays skin scratching and abnormal immune disorders. In the past few years, much progress has been made in our understanding of Itch-promoted protein ubiquitination, modulation of its ligase activity by upstream kinases, and the kinase-ligase interaction in T cell differentiation and tolerance induction.
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