[HTML][HTML] Zebularine inhibits human acute myeloid leukemia cell growth in vitro in association with p15INK4B demethylation and reexpression
SA Scott, A Lakshimikuttysamma, DP Sheridan… - Experimental …, 2007 - Elsevier
OBJECTIVE: The p15INK4B tumor suppressor is frequently silenced by promoter
hypermethylation in myelodysplastic syndrome and acute myeloid leukemia (AML).
Clinically approved DNA methylation inhibitors, such as 5-aza-2'-deoxycytidine, can reverse
p15INK4B promoter methylation, but widespread clinical use of these inhibitors is limited by
their toxicity and instability in aqueous solution. The cytidine analog zebularine is a stable
DNA methylation inhibitor that has minimal toxicity in vitro and in vivo. We evaluated …
hypermethylation in myelodysplastic syndrome and acute myeloid leukemia (AML).
Clinically approved DNA methylation inhibitors, such as 5-aza-2'-deoxycytidine, can reverse
p15INK4B promoter methylation, but widespread clinical use of these inhibitors is limited by
their toxicity and instability in aqueous solution. The cytidine analog zebularine is a stable
DNA methylation inhibitor that has minimal toxicity in vitro and in vivo. We evaluated …
