[HTML][HTML] Mass kinetics of apolipoprotein AI in interstitial fluid after administration of intravenous apolipoprotein AI/lecithin discs in humans
R Hovorka, MN Nanjee, CJ Cooke, IP Miller… - Journal of lipid …, 2006 - ASBMB
Apolipoprotein kinetics are customarily determined by modeling time curves of specific
radioactivity or isotopic enrichment in plasma after intravenous infusion of radiolabeled
lipoproteins or stable isotope-enriched amino acids. However, this provides no information
on the fractional rate of transfer of the apolipoprotein from plasma to interstitial fluid (k p-if) or
its mean residence time in interstitial fluid (MRT if). To determine these parameters for a
pharmacologic dose of exogenous apolipoprotein AI (apoA-I) given intravenously as apoA …
radioactivity or isotopic enrichment in plasma after intravenous infusion of radiolabeled
lipoproteins or stable isotope-enriched amino acids. However, this provides no information
on the fractional rate of transfer of the apolipoprotein from plasma to interstitial fluid (k p-if) or
its mean residence time in interstitial fluid (MRT if). To determine these parameters for a
pharmacologic dose of exogenous apolipoprotein AI (apoA-I) given intravenously as apoA …