Platelets play an important role in hemostasis, thrombosis, and antimicrobial host defense
and are also involved in the induction of inflammation, tissue repair, and tumor metastasis.
We have previously characterized the platelet aggregation-inducing sialoglycoprotein
(Aggrus/gp44) overexpressed on the surface of tumor cells. Because a platelet aggregation-
neutralizing 8F11 monoclonal antibody that could specifically recognize Aggrus suppressed
tumor-induced platelet aggregation, we have previously purified Aggrus by 8F11-affinity …