[HTML][HTML] Embryonic fibroblasts that are genetically deficient in low density lipoprotein receptor-related protein demonstrate increased activity of the urokinase receptor …
AM Weaver, IM Hussaini, A Mazar, J Henkin… - Journal of Biological …, 1997 - ASBMB
Low density lipoprotein receptor-related protein (LRP) mediates the endocytosis of diverse
ligands, including urokinase plasminogen activator (uPA) and its receptor, uPAR, which
have been implicated in cellular migration. The purpose of this study was to determine
whether LRP affects cellular migration. Murine embryonic fibroblasts (MEF) that are LRP-
deficient due to targeted gene disruption and exotoxin selection (MEF-2), heterozygous
fibroblasts (PEA-10), and wild-type fibroblasts (MEF-1) were compared. When cultures were …
ligands, including urokinase plasminogen activator (uPA) and its receptor, uPAR, which
have been implicated in cellular migration. The purpose of this study was to determine
whether LRP affects cellular migration. Murine embryonic fibroblasts (MEF) that are LRP-
deficient due to targeted gene disruption and exotoxin selection (MEF-2), heterozygous
fibroblasts (PEA-10), and wild-type fibroblasts (MEF-1) were compared. When cultures were …