The glomerular endothelium: new insights on function and structure
B Haraldsson, J Nyström - Current opinion in nephrology and …, 2012 - journals.lww.com
B Haraldsson, J Nyström
Current opinion in nephrology and hypertension, 2012•journals.lww.comMore conclusive endothelium-specific, inducible transgenic mouse models are still lacking.
There are studies, however, showing that the glomerular cell components interact much
more intensely than previously recognized. Thus, the glomerular barrier seems to maintain
its highly selective properties by an orchestra of intercellular signaling between mesangial,
endothelial and epithelial cells. The result resembles a fine-tuned symphony of which we
have heard only small parts, and understood even less.
There are studies, however, showing that the glomerular cell components interact much
more intensely than previously recognized. Thus, the glomerular barrier seems to maintain
its highly selective properties by an orchestra of intercellular signaling between mesangial,
endothelial and epithelial cells. The result resembles a fine-tuned symphony of which we
have heard only small parts, and understood even less.
Summary
More conclusive endothelium-specific, inducible transgenic mouse models are still lacking. There are studies, however, showing that the glomerular cell components interact much more intensely than previously recognized. Thus, the glomerular barrier seems to maintain its highly selective properties by an orchestra of intercellular signaling between mesangial, endothelial and epithelial cells. The result resembles a fine-tuned symphony of which we have heard only small parts, and understood even less.
Lippincott Williams & Wilkins