Update on the glomerular filtration barrier
G Jarad, JH Miner - Current opinion in nephrology and …, 2009 - journals.lww.com
G Jarad, JH Miner
Current opinion in nephrology and hypertension, 2009•journals.lww.comWe suggest viewing the GFB as a dynamic rather than as a rigid barrier, requiring three
healthy layers and a hemodynamic steady state. Multiple challenges to studying the
endothelium, the tubular handling of albumin, and the role of hemodynamic forces will
require new tools, new hypotheses, and open minds.
healthy layers and a hemodynamic steady state. Multiple challenges to studying the
endothelium, the tubular handling of albumin, and the role of hemodynamic forces will
require new tools, new hypotheses, and open minds.
Summary
We suggest viewing the GFB as a dynamic rather than as a rigid barrier, requiring three healthy layers and a hemodynamic steady state. Multiple challenges to studying the endothelium, the tubular handling of albumin, and the role of hemodynamic forces will require new tools, new hypotheses, and open minds.
Lippincott Williams & Wilkins