Glial cell line-derived neurotrophic factor (GDNF) induces neuritogenesis in the cochlear spiral ganglion via neural cell adhesion molecule (NCAM)
S Euteneuer, KH Yang, E Chavez, A Leichtle… - Molecular and Cellular …, 2013 - Elsevier
Glial cell line-derived neurotrophic factor (GDNF) increases survival and neurite extension of
spiral ganglion neurons (SGNs), the primary neurons of the auditory system, via yet
unknown signaling mechanisms. In other cell types, signaling is achieved by the GPI-linked
GDNF family receptor α1 (GFRα1) via recruitment of transmembrane receptors: Ret (re-
arranged during transformation) and/or NCAM (neural cell adhesion molecule). Here we
show that GDNF enhances neuritogenesis in organotypic cultures of spiral ganglia from 5 …
spiral ganglion neurons (SGNs), the primary neurons of the auditory system, via yet
unknown signaling mechanisms. In other cell types, signaling is achieved by the GPI-linked
GDNF family receptor α1 (GFRα1) via recruitment of transmembrane receptors: Ret (re-
arranged during transformation) and/or NCAM (neural cell adhesion molecule). Here we
show that GDNF enhances neuritogenesis in organotypic cultures of spiral ganglia from 5 …
