[PDF][PDF] Unraveling the NALP-3/IL-1β inflammasome: a big lesson from a small mutation
CA Dinarello - Immunity, 2004 - cell.com
CA Dinarello
Immunity, 2004•cell.comCytokine-mediated inflammation is a target for novel therapies as well as for fundamental
research. A single amino acid mutation in the NALP-3 gene controlling the activation of
caspase-1 results in increased processing of the inactive IL-1β precursor and release of the
active cytokine. Blocking IL-1 receptors arrests inflammation in humans with the mutation.
research. A single amino acid mutation in the NALP-3 gene controlling the activation of
caspase-1 results in increased processing of the inactive IL-1β precursor and release of the
active cytokine. Blocking IL-1 receptors arrests inflammation in humans with the mutation.
Cytokine-mediated inflammation is a target for novel therapies as well as for fundamental research. A single amino acid mutation in the NALP-3 gene controlling the activation of caspase-1 results in increased processing of the inactive IL-1β precursor and release of the active cytokine. Blocking IL-1 receptors arrests inflammation in humans with the mutation.
cell.com