HLA-DR and-DQ genotypes of celiac disease patients serologically typed to be non-DR3 or non-DR5/7
A Spurkland, LM Sollid, I Polanco, F Vartdal… - Human immunology, 1992 - Elsevier
The susceptibility to develop celiac disease (CD) seems to be primarily associated to a
particular HLA-DQ α/ß heterodimer encoded by the DQA1∗ 0501 and DOB1∗ 0201 alleles,
in cis position on the DR3-DQ2 haplotype or in trans position by DR5-DQ7/DR7-DQ2
heterozygotes. However, exceptional patients exist who are neither DR3 nor DR5/DR7,
particularly among Southern European populations. We therefore examined the DRB1,
DQA1, and DQB1 alleles of 13 Spanish CD patients who were serologically typed to be …
particular HLA-DQ α/ß heterodimer encoded by the DQA1∗ 0501 and DOB1∗ 0201 alleles,
in cis position on the DR3-DQ2 haplotype or in trans position by DR5-DQ7/DR7-DQ2
heterozygotes. However, exceptional patients exist who are neither DR3 nor DR5/DR7,
particularly among Southern European populations. We therefore examined the DRB1,
DQA1, and DQB1 alleles of 13 Spanish CD patients who were serologically typed to be …