[HTML][HTML] Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors
Y Weng, SJ Siciliano, KE Waldburger… - Journal of Biological …, 1998 - ASBMB
IP10 and MIG are two members of the CXC branch of the chemokine superfamily whose
expression is dramatically up-regulated by interferon (IFN)-γ. The proteins act largely on
natural killer (NK)-cells and activated T-cells and have been implicated in mediating some of
the effects of IFN-γ and lipopolysaccharides (LPSs), as well as T-cell-dependent anti-tumor
responses. Recently both chemokines have been shown to be functional agonists of the
same G-protein-coupled receptor, CXCR3. We now report the pharmacological …
expression is dramatically up-regulated by interferon (IFN)-γ. The proteins act largely on
natural killer (NK)-cells and activated T-cells and have been implicated in mediating some of
the effects of IFN-γ and lipopolysaccharides (LPSs), as well as T-cell-dependent anti-tumor
responses. Recently both chemokines have been shown to be functional agonists of the
same G-protein-coupled receptor, CXCR3. We now report the pharmacological …