The death domain motif found in Fas (Apo-1) and TNF receptor is present in proteins involved in apoptosis and axonal guidance
K Hofmann - FEBS letters, 1995 - Elsevier
FEBS letters, 1995•Elsevier
The interaction of Fas (Apo-1) and TNF receptor-1 with their respective ligands can lead to
cell death. The so-called death domain, a sequence motif present in the cytoplasmic portion
of the two receptors, has been identified as a critical structural element involved in signal
transduction that leads to apoptosis. Here we describe several additional proteins which
contain a death domain. Novel members of this family include proteins known to be
implicated not only in apoptosis but also in neuron guidance.
cell death. The so-called death domain, a sequence motif present in the cytoplasmic portion
of the two receptors, has been identified as a critical structural element involved in signal
transduction that leads to apoptosis. Here we describe several additional proteins which
contain a death domain. Novel members of this family include proteins known to be
implicated not only in apoptosis but also in neuron guidance.
The interaction of Fas (Apo-1) and TNF receptor-1 with their respective ligands can lead to cell death. The so-called death domain, a sequence motif present in the cytoplasmic portion of the two receptors, has been identified as a critical structural element involved in signal transduction that leads to apoptosis. Here we describe several additional proteins which contain a death domain. Novel members of this family include proteins known to be implicated not only in apoptosis but also in neuron guidance.
Elsevier