Increased orexin and melanin-concentrating hormone expression in the perifornical lateral hypothalamus of rats prone to overconsuming a fat-rich diet
I Morganstern, GQ Chang, O Karatayev… - Pharmacology …, 2010 - Elsevier
The goal of this study is to examine the expression pattern of orexigenic peptides, orexin
(OX) and melanin-concentrating hormone (MCH), in the perifornical lateral hypothalamus
(PFLH) in subpopulations of Sprague–Dawley rats differing in their propensity to
overconsume a high-fat diet. Immediately after an initial 5-day screening test that predicts
long-term consumption, rats identified as high-fat consumers (HFC), ingesting 35% more
calories of a high-fat relative to low-fat chow diet, had significantly elevated mRNA …
(OX) and melanin-concentrating hormone (MCH), in the perifornical lateral hypothalamus
(PFLH) in subpopulations of Sprague–Dawley rats differing in their propensity to
overconsume a high-fat diet. Immediately after an initial 5-day screening test that predicts
long-term consumption, rats identified as high-fat consumers (HFC), ingesting 35% more
calories of a high-fat relative to low-fat chow diet, had significantly elevated mRNA …