Reduction of Stat3 activity attenuates HIV-induced kidney injury
X Feng, TC Lu, PY Chuang, W Fang… - Journal of the …, 2009 - journals.lww.com
HIV-1 Nef induces podocyte proliferation and dedifferentiation by activating the Stat3 and
MAPK1, 2 pathways. Activation of Stat3 also occurs in human kidneys affected by HIV-
associated nephropathy (HIVAN), but its contribution to the development of HIVAN is
unknown. Here, we generated HIV-1 transgenic mice (Tg26) with either 75% Stat3 activity
(Tg26-SA/+) or 25% Stat3 activity (Tg26-SA/−). The kidneys of Tg26-SA/+ mice, but not Tg26-
SA/− mice, showed increased Stat3 phosphorylation. The Tg26-SA/+ phenotype was not …
MAPK1, 2 pathways. Activation of Stat3 also occurs in human kidneys affected by HIV-
associated nephropathy (HIVAN), but its contribution to the development of HIVAN is
unknown. Here, we generated HIV-1 transgenic mice (Tg26) with either 75% Stat3 activity
(Tg26-SA/+) or 25% Stat3 activity (Tg26-SA/−). The kidneys of Tg26-SA/+ mice, but not Tg26-
SA/− mice, showed increased Stat3 phosphorylation. The Tg26-SA/+ phenotype was not …