[HTML][HTML] An arginine-rich motif of ring finger protein 4 (RNF4) oversees the recruitment and degradation of the phosphorylated and SUMOylated Krüppel-associated …
Krüppel-associated box domain-associated protein 1 (KAP1) is a universal transcriptional
corepressor that undergoes multiple posttranslational modifications (PTMs), including
SUMOylation and Ser-824 phosphorylation. However, the functional interplay of KAP1 PTMs
in regulating KAP1 turnover during DNA damage response remains unclear. To decipher
the role and cross-talk of multiple KAP1 PTMs, we show here that DNA double strand break-
induced KAP1 Ser-824 phosphorylation promoted the recruitment of small ubiquitin-like …
corepressor that undergoes multiple posttranslational modifications (PTMs), including
SUMOylation and Ser-824 phosphorylation. However, the functional interplay of KAP1 PTMs
in regulating KAP1 turnover during DNA damage response remains unclear. To decipher
the role and cross-talk of multiple KAP1 PTMs, we show here that DNA double strand break-
induced KAP1 Ser-824 phosphorylation promoted the recruitment of small ubiquitin-like …