Lactate production and neurotransmitters; evidence from microdialysis studies
T Uehara, T Sumiyoshi, H Itoh, K Kurata - Pharmacology Biochemistry and …, 2008 - Elsevier
Recent studies have found that lactate metabolism plays a significant role in energy supply
during acute neural activation in the brain. We will review evidence from microdialysis
studies for a relationship between neurotransmitters and lactate production, as revealed in
studies of the effects of psychotropic drugs on stress-induced enhancement of extracellular
lactate concentrations. Glutamate enhances stress-induced lactate production via activation
of N-methyl-D-asparate receptors, and is affected by uptake of glutamate through glutamate …
during acute neural activation in the brain. We will review evidence from microdialysis
studies for a relationship between neurotransmitters and lactate production, as revealed in
studies of the effects of psychotropic drugs on stress-induced enhancement of extracellular
lactate concentrations. Glutamate enhances stress-induced lactate production via activation
of N-methyl-D-asparate receptors, and is affected by uptake of glutamate through glutamate …
