Kainic acid-induced seizures stimulate increased expression of nerve growth factor mRNA in rat hippocampus
C Gall, K Murray, PJ Isackson - Molecular brain research, 1991 - Elsevier
The influence of kainic acid (KA)-induced limbic seizure activity on the expression of mRNA
for nerve growth factor (NGF) in adult rat brain was studied using in situ hybridization and S1
nuclease protection techniques with RNA probes complementary to murine and rat NGF
mRNA. Within hippocampus, intracerebroventricular injection of 0.5 μg KA caused a
dramatic bilateral increase in hybridization of the 35 S-labeled cRNA within stratum
granulosum. This increase was first evident 1 h post-KA, appeared maximal at …
for nerve growth factor (NGF) in adult rat brain was studied using in situ hybridization and S1
nuclease protection techniques with RNA probes complementary to murine and rat NGF
mRNA. Within hippocampus, intracerebroventricular injection of 0.5 μg KA caused a
dramatic bilateral increase in hybridization of the 35 S-labeled cRNA within stratum
granulosum. This increase was first evident 1 h post-KA, appeared maximal at …
