With advancing age, the balance between the amounts of old bone removed and new bone
formed during the remodelling process becomes negative. In the past, it was commonly
thought that skeletal involution was the result of age-related changes in other organs, and in
particular from the decline in ovarian function in women at menopause. Nonetheless, with
regard to emerging epidemiologic studies, the hypothesis suggesting that age-related
changes such as inflammatory modifications importantly account for age-related bone loss is …