The metabolism of amyloid β peptide (Aβ) in the brain is crucial to the pathogenesis of
Alzheimer disease. A body of evidence suggests that Aβ is actively transported from brain
parenchyma to blood across the blood-brain barrier (BBB), although the precise mechanism
remains unclear. To unravel the cellular and molecular mechanism of Aβ transport across
the BBB, we established a new in vitro model of the initial internalization step of Aβ transport
using TR-BBB cells, a conditionally immortalized endothelial cell line from rat brain. We …