[8] Monoclonal antibodies specific for the native, disease-associated isoform of the prion protein
C Korth, P Streit, B Oesch - Methods in enzymology, 1999 - Elsevier
Publisher Summary Prion diseases are transmissible neurodegenerative diseases in
humans and other mammals. The infectious agent, the prion, is thought to comprise a
conformational isoform—PrP Sc—of a membrane-anchored ubiquitous host protein PrP C of
unknown function. During the replication of prions it is hypothesized that disease-specific
PrP Sc converts host-resident PrP C, possibly with the help of other cofactors, to new PrP Sc
molecules. The two isoforms of the prion protein—PrP C and PrP Sc have the same amino …
humans and other mammals. The infectious agent, the prion, is thought to comprise a
conformational isoform—PrP Sc—of a membrane-anchored ubiquitous host protein PrP C of
unknown function. During the replication of prions it is hypothesized that disease-specific
PrP Sc converts host-resident PrP C, possibly with the help of other cofactors, to new PrP Sc
molecules. The two isoforms of the prion protein—PrP C and PrP Sc have the same amino …