MicroRNAs involved in skeletal muscle development and their roles in rhabdomyosarcoma pathogenesis
J Novák, J Vinklárek… - Pediatric blood & …, 2013 - Wiley Online Library
J Novák, J Vinklárek, J Bienertová‐Vašků, O Slabý
Pediatric blood & cancer, 2013•Wiley Online LibraryMicroRNAs (miRs) are small non‐coding RNAs known to fulfill various functions in tissue
development, function, and pathogenesis of various diseases, including cancer.
Rhabdomyosarcoma (RMS) represents the most common soft tissue tumor in the pediatric
population. miRs have been shown to play important roles in RMS pathogenesis and some
of the studies suggest their potential as diagnostic, prognostic, and even therapeutic tools
facilitating better management of this disease. This review summarizes current information …
development, function, and pathogenesis of various diseases, including cancer.
Rhabdomyosarcoma (RMS) represents the most common soft tissue tumor in the pediatric
population. miRs have been shown to play important roles in RMS pathogenesis and some
of the studies suggest their potential as diagnostic, prognostic, and even therapeutic tools
facilitating better management of this disease. This review summarizes current information …
Abstract
MicroRNAs (miRs) are small non‐coding RNAs known to fulfill various functions in tissue development, function, and pathogenesis of various diseases, including cancer. Rhabdomyosarcoma (RMS) represents the most common soft tissue tumor in the pediatric population. miRs have been shown to play important roles in RMS pathogenesis and some of the studies suggest their potential as diagnostic, prognostic, and even therapeutic tools facilitating better management of this disease. This review summarizes current information about the role of miRs in the development of normal skeletal muscle and their deregulation in RMS. Pediatr Blood Cancer 2013;60:1739–1746. © 2013 Wiley Periodicals, Inc.
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