Host cells respond to viral infections by synthesizing and producing antiviral molecules such
as type I interferons (IFN). The Kaposi sarcoma-associated herpesvirus (KSHV) encodes
multiple proteins expressed during the lytic replication cycle that alter the antiviral response
of the host. Considering that in Kaposi sarcoma lesions and primary effusion lymphoma cells
KSHV is latent in the vast majority of cells, we were interested in determining whether
latently expressed viral proteins have the ability to modulate IFN synthesis. The latency …