A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis
BACKGROUND: Commensal microbiota play a critical role in maintaining oral tolerance.
The effect of food allergy on the gut microbial ecology remains unknown. OBJECTIVE: We
sought to establish the composition of the gut microbiota in experimental food allergy and its
role in disease pathogenesis. METHODS: Food allergy–prone mice with a gain-of-function
mutation in the IL-4 receptor α chain (Il4raF709) and wild-type (WT) control animals were
subjected to oral sensitization with chicken egg ovalbumin (OVA). Enforced tolerance was …
The effect of food allergy on the gut microbial ecology remains unknown. OBJECTIVE: We
sought to establish the composition of the gut microbiota in experimental food allergy and its
role in disease pathogenesis. METHODS: Food allergy–prone mice with a gain-of-function
mutation in the IL-4 receptor α chain (Il4raF709) and wild-type (WT) control animals were
subjected to oral sensitization with chicken egg ovalbumin (OVA). Enforced tolerance was …