[HTML][HTML] Short term voluntary overfeeding disrupts brain insulin control of adipose tissue lipolysis
T Scherer, C Lindtner, E Zielinski, J O'Hare… - Journal of biological …, 2012 - ASBMB
Insulin controls fatty acid (FA) release from white adipose tissue (WAT) through direct effects
on adipocytes and indirectly through hypothalamic signaling by reducing sympathetic
nervous system outflow to WAT. Uncontrolled FA release from WAT promotes lipotoxicity,
which is characterized by inflammation and insulin resistance that leads to and worsens type
2 diabetes. Here we tested whether early diet-induced insulin resistance impairs the ability
of hypothalamic insulin to regulate WAT lipolysis and thus contributes to adipose tissue …
on adipocytes and indirectly through hypothalamic signaling by reducing sympathetic
nervous system outflow to WAT. Uncontrolled FA release from WAT promotes lipotoxicity,
which is characterized by inflammation and insulin resistance that leads to and worsens type
2 diabetes. Here we tested whether early diet-induced insulin resistance impairs the ability
of hypothalamic insulin to regulate WAT lipolysis and thus contributes to adipose tissue …