[HTML][HTML] MyD88, an adapter protein involved in interleukin-1 signaling

K Burns, F Martinon, C Esslinger, H Pahl… - Journal of biological …, 1998 - ASBMB
MyD88 has a modular organization, an N-terminal death domain (DD) related to the
cytoplasmic signaling domains found in many members of the tumor necrosis factor receptor
(TNF-R) superfamily, and a C-terminal Toll domain similar to that found in the expanding
family of Toll/interleukin-1-like receptors (IL-1R). This dual domain structure, together with
the following observations, supports a role for MyD88 as an adapter in IL-1 signal
transduction; MyD88 forms homodimers in vivo through DD-DD and Toll-Toll interactions …