Epigenetic disruption has been implicated in many diseases of aging, and age-associated
DNA methylation changes at specific genomic loci in humans are strongly correlated with
chronological age. The aim of this study was to explore the specificity of selected age-
associated differentially methylated positions (aDMPs) identified in human epidemiological
studies by quantifying DNA methylation across multiple tissues in homologous regions of the
murine genome. We selected four high-confidence aDMPs (located in the vicinity of the …