Expression of Notch ligands, Jagged1, 2 and Delta1 in antigen presenting cells in mice

E Yamaguchi, S Chiba, K Kumano, A Kunisato… - Immunology letters, 2002 - Elsevier
Notch1 is indispensable for T cell development. It is anticipated that Notch1 and other Notch
receptors expressed on the surface of thymic T cell precursors are activated by ligands
present on environmental cells, including antigen presenting cells (APCs), and involved in
positive and negative selections. Notch receptors on peripheral T cells may also be
activated by ligands on APCs. Here, we examined the expression pattern of three Notch
ligands, Jagged1, 2 and Delta1 in APCs by an immunofluorescence cell staining method …