Lysine 419 targets human glucocorticoid receptor for proteasomal degradation
AD Wallace, Y Cao, S Chandramouleeswaran… - Steroids, 2010 - Elsevier
Glucocorticoid receptors (GRs) are members of a highly conserved family of ligand
dependent transcription factors which following hormone binding undergo homologous
down-regulation reducing the levels of receptor protein. This decline in human GR (hGR) is
due in part to a decrease in protein receptor stability that may limit cellular responsiveness to
ligand. To examine the role of the proteasome protein degradation pathway in steroid-
dependent hGR responsiveness, we utilized the proteasomal inhibitors MG-132, β-lactone …
dependent transcription factors which following hormone binding undergo homologous
down-regulation reducing the levels of receptor protein. This decline in human GR (hGR) is
due in part to a decrease in protein receptor stability that may limit cellular responsiveness to
ligand. To examine the role of the proteasome protein degradation pathway in steroid-
dependent hGR responsiveness, we utilized the proteasomal inhibitors MG-132, β-lactone …